Membrane Trafficking: Returning to the Fold(ER)
نویسندگان
چکیده
منابع مشابه
Membrane Trafficking: Returning to the Fold(ER)
Retrieval mechanisms are essential to dynamically maintain the composition and functional homeostasis of secretory organelles. A recent study has identified a novel class of cargo receptor that retrieves a specific subset of escaped ER folding machinery from the Golgi.
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The primary cilium has been found to be associated with a number of cellular signaling pathways, such as vertebrate hedgehog signaling, and implicated in the pathogenesis of diseases affecting multiple organs, including the neural tube, kidney, and brain. The primary cilium is the site where a subset of the cell's membrane proteins is enriched. However, pathways that target and concentrate memb...
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Having a drug that works clinically, but without a clear mechanism, is like having a key that can be tried on many doors—eventually one will open, but what will be found? The paper by Burstein and colleagues (1) in this issue of Cephalalgia describes an unexpected connection between migraine and membrane trafficking associated with mechanical pain. In an elegant series of experiments, they show...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2015
ISSN: 0960-9822
DOI: 10.1016/j.cub.2015.02.007